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Proteintech
ASH2L Polyclonal Antibody
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Product Details
12331-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
Storage buffer
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Product Specific Information
Immunogen sequence: HGYPLEHPF NKDGYRYILA EPDPHAPDPE KLELDCWAGK PIPGDLYRAC LYERVLLALH DRAPQLKISD DRLTVVGEKG YSMVRASHGV RKGAWYFEIT VDEMPPDTAA RLGWSQPLGN LQAPLGYDKF SYSWRSKKGT KFHQSIGKHY SSGYGQGDVL GFYINLPEDT ETAKSLPDTY KDKALIKFKS YLYFEEKDFV DKAEKSLKQT PHSEIIFYKN GVNQGVAYKD IFEGVYFPAI SLYKSCTVSI NFGPCFKYPP KDLTYRPMSD MGWGAVVEHT LADVLYHVET EVDGRRSPPW EP (329-628 aa encoded by BC015936)
Target Information
The human ASH2L gene encodes a 628 amino acid protein known as ASH2L1, or isoform 1, which contains a nuclear localization signal and PHD finger motif, suggesting that the gene product functions as a transcription regulator. Its predicted molecular weight is 68.7kDa. Alternative splicing results in possible isoforms at 60 kDa & 56.5 kDa). Human ASH2L proteins are 60% homologous to Drosophila ash2, which positively regulates expression of certain genes in early development, and contain similar, but not identical, domains, including a zinc finger motif. Homology to mouse ASH2L is 90%. ASH2L is predominantly expressed in adult heart and testis and fetal lung and liver, with barely detectable expression in adult lung, liver, kidney, prostate, and peripheral leukocytes as well as leukemia cell lines with erythroid and megakaryocytic potential, such as K562, Hel and Dami. Differentiation inducers (e.g. phorbol ester and hemin) cause different expression patterns in these cell lines, suggesting that ASH2L plays a role in hematopoiesis and is associated with particular types of leukemia. In addition ASH2L has been suggested to interact with beta-tubulin and beta-catenin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ASH 2; ash2 (absent, small, or homeotic)-like; ASH2 LIKE; ASH2 like protein; ASH2-like protein; Bre 2; Set1/Ash2 histone methyltransferase complex subunit ASH2
Gene Aliases: ASH2; ASH2L; ASH2L1; ASH2L2; Bre2
UniProt ID: (Human) Q9UBL3, (Mouse) Q91X20
Entrez Gene ID: (Human) 9070, (Mouse) 23808
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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