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Proteintech
ARL3 Polyclonal Antibody
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Product Details
10961-1-AP
Species Reactivity
Published species
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: MGLLSILRK LKSAPDQEVR ILLLGLDNAG KTTLLKQLAS EDISHITPTQ GFNIKSVQSQ GFKLNVWDIG GQRKIRPYWK NYFENTDILI YVIDSADRKR FEETGQELAE LLEEEKLSCV PVLIFANKQD LLTAAPASEI AEGLNLHTIR DRVWQIQSCS ALTGEGVQDG MNWVCKNVNA KKK (1-182 aa encoded by BC009841)
Target Information
ADP-ribosylation factors (ARFs) are low molecular weight GTP-binding proteins belonging to the RAS superfamily. The predicted 182-amino acid ARL3 (ADP-ribosylation like factor) protein shares 97% amino acid identity with rat ARLl3 and 43% identity with human ARF1. Like the ARFs, ARL3 has a glycine at position 2, the site of N myristoylation, and lacks cysteine residues near the C terminus, which are found in other members of the RAS family. Northern blot analysis detected a 1-kb ARL3 transcript in all tissues tested, with highest expression in heart and lung, and lower expression in brain, liver, kidney, ovary, and testis. A 5.5-kb transcript was also detected in most tissues, with highest expression in brain. Immunoblot analysis detected ARL3 in human tumor cell lines but not in normal rodent cells. Although ARL3 binds GTP, it is devoid of activity in the cholera toxin-dependent ADP-ribosylation of Gs, and is therefore classified as an ARF-like protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ADP-ribosylation factor like GTPase 3; ADP-ribosylation factor-like 3; ADP-ribosylation factor-like protein 3; ADP-ribosylation-like 3; ARD3; ARF-like 3; Arf-like protein 3
Gene Aliases: ARFL3; ARL3
UniProt ID: (Human) P36405, (Rat) P37996, (Mouse) Q9WUL7
Entrez Gene ID: (Human) 403, (Rat) 64664, (Mouse) 56350
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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