Invitrogen

ARF1/ARF3/ARF5/ARF6 Polyclonal Antibody

View all (3) ARF Pan antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
ARF1/ARF3/ARF5/ARF6 Polyclonal Antibody

Product Details

PA5-114874

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ARF3(Accession P61204), corresponding to amino acid residues H146-K181.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2899510

Product Specific Information

Antibody detects endogenous levels of total ARF3.

Target Information

ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ADP-ribosylation factor 1; ADP-ribosylation factor 2; ADP-ribosylation factor 3; ADP-ribosylation factor 4; ADP-ribosylation factor 5; ADP-ribosylation factor 6; ARF; Liver regeneration-related protein LRRG202; pan ARF; small GTP binding protein

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Gene Aliases: Ac1-253; ARF1; ARF2; ARF3; ARF4; ARF5; ARF6

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UniProt ID: (Human) P84077, (Human) P61204, (Human) P18085, (Human) P84085, (Human) P62330, (Rat) P84079, (Rat) P84082, (Rat) P61206, (Rat) P61751, (Rat) P84083, (Rat) P62332

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Entrez Gene ID: (Human) 375, (Human) 377, (Human) 378, (Human) 381, (Human) 382, (Rat) 64310, (Rat) 79119, (Rat) 140940, (Rat) 79120, (Rat) 79117, (Rat) 79121

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Function(s)
magnesium ion binding GTPase activity receptor signaling protein activity protein binding GTP binding GDP binding poly(A) RNA binding phospholipase D activator activity ARF guanyl-nucleotide exchange factor activity epidermal growth factor receptor binding thioesterase binding protein N-terminus binding protein homodimerization activity
Process(es)
small GTPase mediated signal transduction protein transport vesicle-mediated transport regulation of receptor internalization phosphatidylinositol biosynthetic process cellular copper ion homeostasis post-Golgi vesicle-mediated transport actin filament organization antigen processing and presentation of exogenous peptide antigen via MHC class II regulation of Arp2/3 complex-mediated actin nucleation very-low-density lipoprotein particle assembly positive regulation of catalytic activity positive regulation of endocytosis positive regulation of calcium ion-dependent exocytosis regulation of defense response to virus by virus positive regulation of protein secretion Golgi to transport vesicle transport long term synaptic depression positive regulation of dendritic spine development synaptic vesicle budding dendritic spine organization lysosomal membrane organization positive regulation of sodium ion transmembrane transport positive regulation of late endosome to lysosome transport positive regulation of ER to Golgi vesicle-mediated transport regulation of phospholipid metabolic process liver development actin cytoskeleton organization positive regulation of actin filament polymerization cortical actin cytoskeleton organization ruffle organization myeloid cell apoptotic process protein localization to cell surface regulation of Rac protein signal transduction protein localization to endosome regulation of filopodium assembly regulation of dendritic spine development positive regulation of establishment of protein localization to plasma membrane establishment of epithelial cell polarity hepatocyte apoptotic process negative regulation of dendrite development retrograde vesicle-mediated transport, Golgi to ER protein ADP-ribosylation epidermal growth factor receptor signaling pathway brain development cell migration activation of phospholipase D activity negative regulation of apoptotic process apical protein localization establishment or maintenance of epithelial cell apical/basal polarity positive regulation of transcription from RNA polymerase II promoter response to axon injury protein localization to cilium regulation of reactive oxygen species metabolic process ER to Golgi vesicle-mediated transport learning positive regulation of GTPase activity dendritic spine development movement of cell or subcellular component cell cycle cell adhesion negative regulation of receptor-mediated endocytosis cell division
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