NeoBiotechnologies

APC/Adenomatous Polyposis Coli/FAP (Tumor Suppressor) Monoclonal Antibody (ALi 12-28)

View all (32) Protein APC antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

324-MSM1-P0

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunocytochemistry (ICC/IF)

1-2 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/10^6 cells
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

ALi 12-28

Immunogen

Recombinant fragment of human APC protein (around aa 1-433)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4, with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C, do not freeze

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Does not react with Mouse

Target Information

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: adenomatosis polyposis coli tumor suppressor; Adenomatous polyposis coli protein; Deleted in polyposis 2.5; FAP; FPC; Protein APC; protein phosphatase 1, regulatory subunit 46; truncated adenomatosis polyposis coli; WNT signaling pathway regulator

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Gene Aliases: APC; BTPS2; DP2; DP2.5; DP3; GS; PPP1R46

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UniProt ID: (Human) P25054

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Entrez Gene ID: (Human) 324

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Function(s)
protein binding beta-catenin binding microtubule binding protein kinase regulator activity protein kinase binding protein complex binding gamma-catenin binding cadherin binding microtubule plus-end binding
Process(es)
mitotic cytokinesis cell fate specification protein complex assembly cellular component disassembly involved in execution phase of apoptosis cellular response to DNA damage stimulus negative regulation of microtubule depolymerization cell cycle arrest mitotic spindle assembly checkpoint cell adhesion establishment or maintenance of cell polarity pattern specification process negative regulation of cell proliferation Wnt signaling pathway cell migration positive regulation of cell migration pancreas development neuron projection development positive regulation of pseudopodium assembly regulation of microtubule-based process response to drug positive regulation of apoptotic process proteasome-mediated ubiquitin-dependent protein catabolic process regulation of cell differentiation positive regulation of protein catabolic process negative regulation of cyclin-dependent protein serine/threonine kinase activity regulation of attachment of spindle microtubules to kinetochore canonical Wnt signaling pathway bicellular tight junction assembly negative regulation of canonical Wnt signaling pathway response to alcohol beta-catenin destruction complex assembly beta-catenin destruction complex disassembly cellular response to nerve growth factor stimulus regulation of glutamate metabolic process
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