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Invitrogen
AP2S1 Polyclonal Antibody
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FIGURE: 1 / 1
AP2S1 Antibody (PA5-88458) in WB
Product Details
PA5-88458
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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RRID
Product Specific Information
Immunogen sequence: MIRFILIQNR AGKTRLAKWY MQFDDDEKQK LIEEVHAVVT VRDAKHTNFV EFRNFKIIYR RYAGLYFCIC VDVNDNNLAY LEAIHNFVEV LNEYFHNVCE LDLVFNFYKV YTVVDEMFLA GEIRETSQTK VLKQLLMLQS LE; Positive Samples: HeLa, LO2, SH-SY5Y, Mouse brain, Mouse kidney, Mouse spleen, Rat brain, Rat spleen; Cellular Location: Cell membrane, Cytoplasmic side, Membrane, Peripheral membrane protein, coated pit
Target Information
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin- coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif. May also play a role in extracellular calcium homeostasis.
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For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: adapter-related protein complex 2 sigma subunit; adapter-related protein complex 2 subunit sigma; Adaptor protein complex AP-2 subunit sigma; adaptor-related protein complex 2 sigma 1 subunit; Adaptor-related protein complex 2 subunit sigma; adaptor-related protein complex 2, sigma 1 subunit; AP-2 complex subunit sigma; AP17-DELTA; Clathrin assembly protein 2 sigma small chain; clathrin assembly protein 2 small chain; Clathrin coat assembly protein AP17; Clathrin coat-associated protein AP17; clathrin-associated protein 17; clathrin-associated/assembly/adaptor protein, small 2 (17kD); HA2 17 kDa subunit; Plasma membrane adaptor AP-2 17 kDa protein; Sigma-adaptin 3b; Sigma2-adaptin
Gene Aliases: AI043088; AP17; AP2S1; CLAPS2; FBH3; FBHOk; HHC3
UniProt ID: (Human) P53680, (Rat) P62744, (Mouse) P62743
Entrez Gene ID: (Human) 1175, (Rat) 65046, (Mouse) 232910
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