Invitrogen

AMPK alpha-1 Monoclonal Antibody (C.961.4)

Advanced Verification
1 Reference
View all (71) AMPK alpha-1 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-14922

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 1 publication 1 publication
Product Specifications

Species Reactivity

Hamster, Human, Mouse, Non-human primate, Rat

Published species

Human

Host/Isotype

Mouse / IgG2b

Class

Monoclonal

Type

Antibody

Clone

C.961.4

Immunogen

Purified recombinant human AMPKa1 protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1602 µg/mL

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10986836

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 5'-AMP-activated protein kinase catalytic subunit alpha-1; 5'-AMP-activated protein kinase, catalytic alpha-1 chain; AAPK2; ACACA kinase; Acetyl-CoA carboxylase kinase; activated protein kinase; AMP -activate kinase alpha 1 subunit; AMP activated protein kinase; AMP-activated protein kinase, alpha 1 catalytic subunit; AMP-activated protein kinase, catalytic, alpha-1; AMPK alpha 1; AMPK alpha-1 chain; AMPK subunit alpha-1; AMPK subunit pAMPK; AMPK-alpha-2 chain; AMPK2; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase; MGC33776; MGC57364; pAMPK; PRKAA; PRKAA2; protein kinase, AMP-activated, alpha 1 catalytic subunit; Tau-protein kinase PRKAA1

View more View less

Gene Aliases: AI194361; AI450832; AL024255; AMPK; AMPK1; AMPKa1; AMPKalpha1; C130083N04Rik; PRKAA1

View more View less

UniProt ID: (Human) Q13131, (Rat) P54645, (Mouse) Q5EG47

View more View less

Entrez Gene ID: (Human) 5562, (Rat) 65248, (Mouse) 105787, (Chinese hamster) 100769574

View more View less

Function(s)
chromatin binding protein kinase activity AMP-activated protein kinase activity cAMP-dependent protein kinase activity protein binding ATP binding protein C-terminus binding kinase binding histone serine kinase activity metal ion binding [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity tau-protein kinase activity [acetyl-CoA carboxylase] kinase activity protein serine/threonine kinase activity eukaryotic elongation factor-2 kinase activator activity nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
activation of MAPK activity glucose metabolic process transcription, DNA-templated regulation of transcription, DNA-templated protein phosphorylation fatty acid biosynthetic process cholesterol biosynthetic process autophagy positive regulation of cell proliferation lipid biosynthetic process response to UV cold acclimation response to gamma radiation positive regulation of autophagy positive regulation of gene expression response to activity Wnt signaling pathway negative regulation of translation fatty acid oxidation response to caffeine cellular response to nutrient levels negative regulation of TOR signaling histone-serine phosphorylation cellular response to glucose starvation response to hydrogen peroxide glucose homeostasis regulation of circadian rhythm negative regulation of apoptotic process positive regulation of gluconeogenesis positive regulation of glycolytic process positive regulation of fatty acid oxidation positive regulation of glucose import rhythmic process negative regulation of lipid catabolic process protein heterooligomerization fatty acid homeostasis regulation of vesicle-mediated transport cellular response to hydrogen peroxide cellular response to ethanol cellular response to prostaglandin E stimulus cellular response to organonitrogen compound cellular response to hypoxia response to camptothecin regulation of energy homeostasis negative regulation of glucose import in response to insulin stimulus lipid metabolic process fatty acid metabolic process steroid biosynthetic process steroid metabolic process cholesterol metabolic process sterol biosynthetic process phosphorylation chromatin modification regulation of peptidyl-serine phosphorylation intracellular signal transduction positive regulation of skeletal muscle tissue development response to hypoxia cell cycle arrest signal transduction macroautophagy positive regulation of cholesterol biosynthetic process negative regulation of glucosylceramide biosynthetic process regulation of signal transduction by p53 class mediator
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support