Abnova

AGER Monoclonal Antibody (1C1)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers
AGER Monoclonal Antibody (1C1)

Product Details

H00000177-M02

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

ELISA (ELISA)

0.3 ng/mL
-

Immunoprecipitation (IP)

1-5 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

1C1

Immunogen

AGER (AAH20669.1, 23 a.a. approximately 404 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: AQNITARIGE PLVLKCKGAP KKPPQRLEWN LNTGRTEAWK VLSPQGGGPW DSVARVLPNG SLFLPAVGIQ DEGIFRCQAM NRNGKETKSN YRVRVYQIPG KPEIVDSASE LTAGVPNKVG TCVSEGSYPA GTLSWHLDGK PLVPNEKGVS VKEQTRRHPE TGLFTLQSEL MVTPARGGDP RPTFSCSFSP GLPRHRALRT APIQPRVWEP VPLEEVQLVV EPEGGAVAPG GTVTLTCEVP AQPSPQIHWM KDGVPLPLPP SPVLILPEIG PQDQGTYSCV ATHSSHGPQE SRAVSISIIE PGEEGPTAGS VGGSGLGTLA LALGILGGLG TAALLIGVIL WQRRQRRGEE RKAPENQEEE EERAELNQSE EPEAGESSTG GP

Target Information

Able to phosphorylate several exogenous substrates and to undergo autophosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Advanced glycosylation end product-specific receptor; RAGE isoform NtRAGE-delta; RAGE isoform sRAGE-delta; RAGE-4 ORF3; receptor for advanced glycation end-products variant 20; Receptor for advanced glycosylation end products; sRAGE

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Gene Aliases: AGER; RAGE; SCARJ1

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UniProt ID: (Human) Q15109

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Entrez Gene ID: (Human) 177

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Function(s)
receptor activity transmembrane signaling receptor activity protein binding identical protein binding S100 protein binding advanced glycation end-product receptor activity high mobility group box 1 binding
Process(es)
regulation of T cell mediated cytotoxicity negative regulation of protein phosphorylation positive regulation of protein phosphorylation negative regulation of endothelial cell proliferation inflammatory response negative regulation of cell adhesion cell surface receptor signaling pathway JAK-STAT cascade brain development glycoprotein metabolic process response to wounding response to fructose positive regulation of autophagy negative regulation of endothelial cell migration positive regulation of gene expression positive regulation of epithelial to mesenchymal transition positive regulation of fibroblast migration response to activity positive regulation of smooth muscle cell migration lung development neuron projection development negative regulation of interleukin-10 production positive regulation of interleukin-12 production negative regulation of collagen biosynthetic process response to vitamin A response to genistein negative regulation of osteoblast proliferation cellular response to drug positive regulation of activated T cell proliferation positive regulation of neuron apoptotic process innate immune response positive regulation of fibroblast proliferation positive regulation of smooth muscle cell proliferation positive regulation of inflammatory response positive regulation of NF-kappaB transcription factor activity response to methylglyoxal calcium ion homeostasis response to hyperoxia positive regulation of phagocytosis, engulfment transdifferentiation cellular response to hydrogen peroxide cellular response to glucose stimulus cellular response to fatty acid cellular response to organic cyclic compound response to selenite ion positive regulation of potassium ion transmembrane transporter activity positive regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process regulation of CD4-positive, alpha-beta T cell activation positive regulation of type B pancreatic cell apoptotic process positive regulation of dendritic cell differentiation
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