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Invitrogen
ADAM10 Polyclonal Antibody
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Product Details
PA5-119642
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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RRID
Product Specific Information
Positive Control: SiHa, HepG2, LOVO, human prostate tissue.
Subcellular Location: Golgi apparatus. Plasma membrane.
Target Information
Proinflammatory cytokine tumor necrosis factor-a (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: a disintegrin and metalloprotease domain 10; a disintegrin and metalloproteinase; ADAM; ADAM 10; ADAMs; CD156c; CDw156; Disintegrin and metalloproteinase domain-containing protein 10; Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease; metalloendopeptidases
Gene Aliases: AD10; AD18; ADAM10; CD156c; CDw156; HsT18717; KUZ; MADM; RAK
UniProt ID: (Human) O14672
Entrez Gene ID: (Human) 102
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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