CREB/ATF1 Antibodies

Target Information

Cyclic AMP response element binding protein (CREB) is a basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44/42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB appears to play an important role in learning and memory.

Synonyms

2310001E10Rik; 3526402H21Rik; Activating transcription factor 1; active transcription factor CREB; ATF1; AV083133; cAMP responsive element binding protein 1; cAMP-dependent transcription factor ATF-1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; Creb; CREB1; Creb-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-dependent transcription factor ATF-1; Cyclic AMP-responsive element-binding protein 1; EWS-ATF1; FUS/ATF-1; Protein TREB36; Ser133; TCR-ATF1; transactivator protein; TREB36