GPD2 Proteins

Protein Information

Mitochondrial glycerophosphate dehydrogenase (EC 1. 1. 99. 5), or GPD2, is located on the outer surface of the inner mitochondrial membrane and catalyzes the unidirectional conversion of glycerol-3-phosphate (G-3-P) to dihydroxyacetone phosphate (DHAP) with concomitant reduction of the enzyme-bound FAD. Together with a cytosolic NAD-linked GPD (GPD1; MIM 138420), GPD2 forms the glycerol phosphate shuttle, which uses the interconversion of G-3-P and DHAP to transfer reducing equivalents into mitochondria, resulting in the reoxidation of NADH formed during glycolysis.

Synonyms

AA408484; AI448216; AU021455; AW494132; FAD-linked glycerol-3-phosphate dehydrogenase; GDH2; Gdm1; glycerol phosphate dehydrogenase 1, mitochondrial; glycerol phosphate dehydrogenase 2, mitochondrial; Glycerol-3-phosophate dehydrogenase 2 (mitochondrial); glycerol-3-phosphate dehydrogenase 2; glycerol-3-phosphate dehydrogenase 2 (mitochondrial); glycerol-3-phosphate dehydrogenase 2, mitochondrial; glycerol-3-phosphate dehydrogenase, mitochondrial; Gpd2; GPDH; GPDH-M; GPDM; GPD-M; mGPDH; mitochondrial glycerol-3-phosphate dehydrogenase; mitochondrial glycerophosphate dehydrogenase; mtGPD; mtGPDH; mtGPDH gene, promoter region and alternative transcripts; Protein TISP38; testicular tissue protein Li 76; TISP38