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Invitrogen
Human TSC22D1 (aa 628-712) Control Fragment Recombinant Protein
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Product Details
RP-108113
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Amino acid sequence
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (74%), Rat (74%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-67456. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
TSC22 domain family protein, or TSC22, is a transcription factor that belongs to the large family of early response genes. This transcriptional repressor is known to act on the C-type natriuretic peptide (CNP) promoter. TSC22 belongs to the TSC-22/Dip/Bun family and is an intracellular protein that may be found in the cytoplasm or nucleus. This transcription factor is known to regulate cell growth, differentiation and cell death and is involved in modulating the transcriptional activity of Smad3 and Smad4. This protein is ubiquitously expressed in most tissues and widely in both fetal and adult tissues. It is generally expressed in aortic endothelial cells, and induced by cytokines, including TGFB. These proteins may be possible therapeutic targets of leukemia and prostate cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Cerebral protein 2; HUCEP-2; Regulatory protein TSC-22; RP11-269C23.2; TGFB-stimulated clone 22 homolog; TGFbeta-stimulated clone 22; transcriptional regulator TSC-22; Transforming growth factor beta-1-induced transcript 4 protein; transforming growth factor beta-stimulated protein TSC-22; TSC22 domain family protein 1; TSC22 domain family, member 1
Gene Aliases: hucep-2; KIAA1994; Ptg-2; TGFB1I4; TSC22; TSC22D1
UniProt ID: (Human) Q15714
Entrez Gene ID: (Human) 8848
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