Invitrogen

Human FAIM3 Synthetic Peptide

Name: Human FAIM3 Synthetic Peptide
Brand: Invitrogen
SKU: PEP-0403

View all (2) FAIM3 proteins

Datasheet

Tech Support

Datasheet

Tech Support

Product Details

PEP-0403

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

Blocking Assay (BLOCK)

Assay-dependent

Product Specifications

Species Reactivity

Human

Class

Synthetic

Type

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

purified

Storage buffer

PBS, pH 7.2, with 0.1% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Product Specific Information

This peptide corresponds to 13 amino acids near the carboxy terminus of human Toso.

PEP-0403 can be used as a blocking peptide with polyclonal antibody PA5-20285.

Target Information

Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FAIM3; Fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc fragment receptor; IgM Fc receptor; IgM FcR; Immunoglobulin mu Fc receptor; Regulator of Fas-induced apoptosis Toso