cGAMP ELISA Kits

ELISA kits are commonly used to measure soluble biomarkers across a variety of research areas. ELISA kits for Human cGAMP can be quantified in various samples, including cell lysate, plasma, supernatant, tissue homogenate.

Invitrogen ELISA kits exist in two formats: Uncoated... ELISA kits are commonly used to measure soluble biomarkers across a variety of research areas. ELISA kits for Human cGAMP can be quantified in various samples, including cell lysate, plasma, supernatant, tissue homogenate.

Invitrogen ELISA kits exist in two formats: Uncoated and Coated.... ELISA kits are commonly used to measure soluble biomarkers across a variety of research areas. ELISA kits for Human cGAMP can be quantified in various samples, including cell lysate, plasma, supernatant, tissue homogenate.

Invitrogen ELISA kits exist in two formats: Uncoated and Coated. Uncoated ELISA kits include all the necessary reagents to coat your own plates and run your assay with maximum flexibility. Coated ELISA kits... ELISA kits are commonly used to measure soluble biomarkers across a variety of research areas. ELISA kits for Human cGAMP can be quantified in various samples, including cell lysate, plasma, supernatant, tissue homogenate.

Invitrogen ELISA kits exist in two formats: Uncoated and Coated. Uncoated ELISA kits include all the necessary reagents to coat your own plates and run your assay with maximum flexibility. Coated ELISA kits are ready-to-use and quality tested for sensitivity, specificity, precision and lot-to-lot consistency.

Target Information

Cyclic GMP-AMP (cGAMP) synthase (cGAS) is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which activates stimulator of interferon genes (STING), leading to activation of the type I interferon (IFN) pathway. In vitro, fibroblasts, macrophages, and dendritic cells isolated from cGAS knockout (cGAS-/-) mice do not produce type I IFNs following DNA transfection or DNA virus infection. Similarly, cells containing a frame-shift mutation in the cGAS locus fail to mount an immune response to HIV and other retroviruses. In vivo, cGAS-/- mice infected with herpes simplex virus 1 (HSV-1) have lower levels of IFN-α and IFN-β, shorter survival times, and higher post-mortem levels of HSV-1 in the brain.

Synonyms

2'3'-Cyclic GMP-AMP; cGAMP; Guanosine-Adenosine 2',3'-cyclic monophosphate

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Invitrogen

2'3'- Cyclic GAMP ELISA Kit

Invitrogen

2'3'- Cyclic GAMP ELISA Kit

Sensitivity 0.08-20 pmol/mL

Assay Range 0.04 pmol/mL

Sample Volume

Cell Lysate

50 µL

Tissue Homogenate

50 µL

Supernatant

50 µL

Time To Result

2 hr 30 min

(45 min hands-on)

Price

Cat # EIAGAMP

96 Tests

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cGAMP ELISA Kits

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