Invitrogen
Rat TNF R1 ELISA Kit
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Product Specifications
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Homogenous (no wash)
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Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
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Detector antibody conjugate
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About This Kit
Rat TNF R1 quantitates rat TNF R1 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant rat TNF R1.
TNFR1 (Tumor necrosis factor receptor 1) belongs to the tumor necrosis factor superfamily, and is one of the major TNF-alpha receptors. TNFR1 plays an important role in mediating, in cytokine mediated signaling, positive regulation of the NF-Kb pathway, positive regulation of angiogenesis, and negative regulation of gene expression. The extracellular domain of TNFR1 is also released into the circulatory system as soluble TNFR1 (sTNFR1). In humans, the TNFR1 gene is located on chromosome 12. Anti-apoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with TNFR1, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of TNFR1 were found to be associated with the autosomal dominant periodic fever syndrome, and the impaired receptor clearance is thought to be a mechanism of the disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : TNFR-1, Tnfr1, Tnfrsf1a
Gene ID : (Rat) 25625
Gene symbol : Tnfrsf1a
Protein Aliases : CD120a, CD120a antigen, MGC19588, p62, p63, sTNFRI, TNFR, TNFR I, Tumor necrosis factor receptor, n-smase activation assoc. factor, sCD120a, soluble CD120a, soluble TNFR1, sTNF RI, sTNFR I, sTNFR1, p55, p60, TNF-R1, TNF-RI, TNFR-I, Tumor necrosis factor receptor 1, Tumor necrosis factor receptor superfamily member 1A, Tumor necrosis factor receptor type I
UniProt ID (Rat) P22934
Performance Guarantee
If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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