Invitrogen
Porcine CCL-4/MIP-1 beta ELISA Kit
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Product Specifications
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Homogenous (no wash)
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Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
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Detector antibody conjugate
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About This Kit
Porcine CCL-4/MIP-1 beta quantitates porcine CCL-4/MIP-1 beta in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant porcine CCL-4/MIP-1 beta.
CCL4 (macrophage inflammatory protein 1-beta, MIP1B) belongs to the intercrine beta (chemokine CC) family. Functionally, CCL4 is involved in chemotactic and proinflammatory effects, and homeostasis. CCL4 is produced by macrophages upon stimulation by bacterial endotoxins. CCL4 recruits and stimulates various inflammatory cells at sites of inflammation. CCL4 is produced by lymphocytes, macrophages and dendritic cells. Both CCL4 and the related protein CCL3 participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells. While both CCL4 and CCL3 exert similar effects on monocytes, their effect on lymphocytes differ, with CCL4 selectively attracting CD4+ lymphocytes and CCL3 selectively attracting CD8+ lymphocytes. Additionally, both have been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. The processed form of CCL4 can induce down-modulation of surface expression of the chemokine receptor CCR5, thus inhibiting the CCR5-mediated entry of HIV-1 in T cells. CCL4 binds with high affinity to CCR5 receptors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : CCL4, MIP-1BETA, MIP1B, SCY4A
Gene ID : (Pig) 396668
Gene symbol : CCL4
Protein Aliases : C-C motif chemokine 4, Macrophage inflammatory protein 1-beta, MGC104418, MGC126025, MGC126026, MIP1-beta, RP23-320E6.8, MIP1beta, MIP-1-beta, Small-inducible cytokine A4
UniProt ID (Pig) Q711P4
Performance Guarantee
If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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