Invitrogen
Mouse/Rat Clusterin ELISA Kit
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Product Specifications
Analytical sensitivity
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Homogenous (no wash)
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Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
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Detector antibody conjugate
Label or dye
About This Kit
Mouse Clusterin quantitates mouse Clusterin in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse Clusterin.
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : AI893575, APOJ, CLI, Clu, D14Ucla3, DAG, Msgp-2, RATTRPM2B, SGP-2, SGP2, SP-40, SP40, Sugp-2, TRPM-2, Trpm2, TRPM2B, Trpmb
Gene ID : (Rat) 24854, (Mouse) 12759
Gene symbol : Clu, Clu
Protein Aliases : Apo-J, Apolipoprotein J, Clusterin, Clustrin, complement lysis inhibitor, DAG, Dimeric acid glycoprotein, HGNC:2095, MGC24903, Clusterin alpha / beta chain, Complement associated protein SP40, GP80, Ku70-binding protein 1 (KUB1), Sulfated glycoprotein 2 (SGP2), Testosterone repressed prostate message 2 (TPRM2B), ApoJ β, ApoJa, ApoJb, apo j, Aging associated protein 4, Apo Jb, ApoJ a, ApoJ alpha, ApoJ b, ApoJ beta, ApoJ α, Apo J alpha, Apo J b, Apo J beta, Apo J α, Apo J β, Apo Ja, Apo J a, SGP-2, Sulfated glycoprotein 2, testosterone repressed prostate message, Testosterone repressed prostate message 2, testosterone repressed prostate message-2, testosterone-repressed prostate message, testostrone-repressed prostate message 2, TRPM-2
UniProt ID (Rat) P05371, (Mouse) Q06890
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If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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