Invitrogen
Human TSG-6 ELISA Kit
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Product Specifications
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Homogenous (no wash)
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Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
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Detector antibody conjugate
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About This Kit
Human TSG-6 quantitates human TSG-6 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human TSG-6.
The TSG6 gene is transcribed in normal fibroblasts and activated by binding of the cytokines TNF alpha and IL-1 at AP-1 and NF-IL6 sites in its promoter. TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein and the adhesion receptor CD44. TSG-6 is highly homologous to CD44, particularly in the hyaluronic acid-binding domain. TSG-6 is found in TNF-treated cells; its expression is rapidly activated by TNF alpha, IL-1 and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells and chondrocytes. The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis. TSG-6 forms a stable complex with components of the serine protease inhibitor, inter-alpha-inhibitor (I alpha I)). TSG-6 potentiates the inhibitory effect of l alpha l on the protease activity of plasmin. Through their cooperative inhibitory effect on plasmin, TSG-6 and l alpha l can modulate the protease network and thus inhibit inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : TNFAIP6, TSG-6, TSG6
Gene ID : (Human) 7130
Gene symbol : TNFAIP6
Protein Aliases : Hyaluronate-binding protein, TNF alpha-induced protein 6, TNF-stimulated gene 6 protein, TSG-6, Tumor necrosis factor alpha-induced protein 6, tumor necrosis factor alpha-inducible protein 6, tumor necrosis factor, alpha induced protein 6, alpha-induced protein 6, Tumor necrosis factor-inducible gene 6 protein, tumor necrosis factor-stimulated gene-6 protein
UniProt ID (Human) P98066
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If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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