Invitrogen
Human ST2 (IL-33R) ELISA Kit
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Product Specifications
Analytical sensitivity
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Homogenous (no wash)
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Contents
Standard (2 vials)
Sample Diluent
Assay Buffer concentrate
Biotinylated Detection Antibody
Streptavidin-HRP
Wash Buffer
Substrate Solution
Stop Solution
Adhesive Plate Covers
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Detector antibody conjugate
Label or dye
About This Kit
The Human ST2 (IL-33R) ELISA Kit is an enzyme-linked immunosorbent assay for the quantitative detection of human ST2 (IL-33R).
IL-33R, also known as ST2, is a receptor for IL-33. It is a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33. IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways. This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13. Two most common isoforms of IL-33R that result from alternative splicing are ST2L - the membrane bound form, and ST2S - the soluble form. The membrane bound form can be released from the cell surface by proteolytic cleavage. The soluble forms have been suggested to act as decoys dampening the IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mouse, IL-33R expression has been shown on ILC2 and Th2 cells. IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : DER4, FIT-1, IL1RL1, IL33R, ST2, ST2L, ST2V, T1
Gene ID : (Human) 9173
Gene symbol : IL1RL1
Protein Aliases : DER4, Fit-1, IL-1 R4, IL1R4, IL-1R4, IL-1RL1, IL-33R, Ly84, ST2, ST2L, ST2V, suppression of tumorigenicity 2, T1, Interleukin1 receptor like 1, sIL 33R, soluble IL 33 Receptor, soluble IL 33R, growth stimulation-expressed, homolog of mouse growth stimulation-expressed, interleukin 1 receptor-like 1, interleukin 1 receptor-related protein, Interleukin-1 receptor-like 1, Protein ST2
UniProt ID (Human) Q01638
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