Invitrogen
Human/Mouse beta-NGF ELISA Kit
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Product Specifications
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Homogenous (no wash)
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Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
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Detector antibody conjugate
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About This Kit
Mouse beta-NGF quantitates mouse beta-NGF in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse beta-NGF.
Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : Beta-NGF, HSAN5, NGF, NGFB
Gene ID : (Human) 4803, (Mouse) 18049
Gene symbol : NGF, Ngf
Protein Aliases : b-NGF, MGC161426, MGC161428, NGFβ, β nerve growth factor, β NGF, βNGF, beta ngf, B nerve growth factor, BetaNGF, bNGF, NGF b, NGF β, NGFbeta, Beta-nerve growth factor, Beta-NGF, nerve growth factor (beta polypeptide), nerve growth factor, beta, beta subunit
UniProt ID (Human) P01138, (Mouse) P01139
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If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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