Invitrogen
Human/Mouse IL-2 R alpha ELISA Kit
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Product Specifications
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Homogenous (no wash)
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Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
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Detector antibody conjugate
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About This Kit
Mouse IL-2 R alpha quantitates mouse IL-2 R alpha in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant mouse IL-2 R alpha.
CD25 (IL2 receptor alpha chain/IL2RA) is a cytokine that plays a role in the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2RA) is a heterotrimeric protein complex with a gamma chain also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2RA, IL2R beta chain (IL2RB), and the IL2R gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric IL2RA chains result in low-affinity receptor, while homodimeric IL2RB chains produce a medium-affinity receptor. The expression of IL2 in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. IL2 is primarily produced by mature T cells. IL2 plays an important role as a growth factor, differentiation factor, and regulator of cell death. IL-2 stimulates the proliferation of B cells, augments natural killer cell activity, and inhibits granulocyte macrophage colony formation. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests a role in the immune response to antigenic stimuli. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : CD25, IDDM10, IL2R, IL2RA, IMD41, Ly-43, p55, TCGFR
Gene ID : (Human) 3559, (Mouse) 16184
Gene symbol : IL2RA, Il2ra
Protein Aliases : CD25, IL-2 receptor subunit alpha, IL-2-RA, IL-2R alpha chain, IL-2R subunit alpha, IL2 RA antibody, Il2ra antibody, IL 2 RA, IL 2 receptor, IL 2R, IL 2R subunit alpha, soluble IL 2 receptor, il-2 receptor alpha, interleukin-2 receptor alpha, IL2 RA, IL2 receptor, IL2 receptor subunit alpha, IL2R subunit alpha, Interleukin2 receptor subunit alpha, sIL 2R, IL2-RA, interleukin 2 receptor, alpha, Interleukin-2 receptor subunit alpha, p55, p55 chain, TAC antigen
UniProt ID (Human) P01589, (Mouse) P01590
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