Invitrogen
Human MR-ProADM ELISA Kit
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Product Specifications
Analytical sensitivity
Assay range
Sample type/volume
Hands-on time
Time-to-result
Homogenous (no wash)
Interassay CV
Intraassay CV
Instrument
Product size
Contents
Shipping conditions
Storage
Protein name
Species (tested)
Species (reported)
Assay kit format
Detector antibody conjugate
Label or dye
About This Kit
The Human Mid regional pro adrenomedullin ELISA Kit (MR ProADM) ELISA quantitates MR ProADM in serum, plasma and other biological fluids.
Principle of the method
The Human Mid regional pro adrenomedullin (MR ProADM) solid phase sandwich ELISA (enzyme linked immunosorbent assay) is designed to measure the amount of the target bound between a matched antibody pair. A target specific antibody has been pre coated in the wells of the supplied microplate. Samples are then added into these wells and bind to the immobilized (capture) antibody. The sandwich is formed by the binding of the second (detector) antibody to the target on a different epitope from the capture antibody. An antibody conjugated with enzyme binds the formed sandwich. After incubation and washing steps to rid the microplate of unbound substances.
Rigorous validation:
Each manufactured lot of this ELISA kit is quality tested for criteria such as sensitivity, specificity, precision, and lot-to-lot consistency. See manual for more information on validation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
MR-proADM, short for mid-regional proadrenomedullin, is a precursor protein that gives rise to the adrenomedullin (ADM) hormone. It is involved in various physiological processes, particularly in the regulation of cardiovascular function and inflammation. Functionally, MR-proADM is associated with vasodilation, blood pressure regulation, and immune response modulation. It acts as a biomarker for endothelial dysfunction and can be used to assess the severity of certain cardiovascular diseases. Elevated levels of MR-proADM have also been linked to systemic inflammation and sepsis. Structurally, MR-proADM is a protein that consists of a chain of amino acids. It undergoes post-translational processing to generate the active form of ADM, which is a shorter peptide consisting of 52 amino acids. Localization-wise, MR-proADM is primarily produced in various tissues, including the adrenal glands, lungs, and endothelial cells lining blood vessels. It is released into the bloodstream and can be measured as a biomarker to provide insight into cardiovascular health and inflammatory conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : ADM, AM, PAMP
Gene ID : (Human) 133
Gene symbol : ADM
Protein Aliases : Mid-regional proadrenomedullin, preproadrenomedullin, Pro-adrenomedullin, proadrenomedullin N-20 terminal peptide
UniProt ID (Human) P35318
Performance Guarantee
If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support