Invitrogen
Human IL-1 alpha ELISA Development Kit (TMB), PeproTech®
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Product Specifications
Analytical sensitivity
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Time-to-result
Homogenous (no wash)
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Protein name
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Species (tested)
Assay kit format
Detector antibody conjugate
Label or dye
About This Kit
900-T11K consists of: 900-T11 (capture antibody, detection antibody, and protein standard), and HRP-17UL (streptavidin HRP-conjugate).
Human IL-1 alpha TMB ELISA Development Kit contains the key components required for the quantitative measurement of natural and/or recombinanthuman IL-1 alpha in a sandwich ELISA format. Human IL-1 alpha TMB ELISA Development Kit contains enough material to assay the target cytokine in at least 1,000 ELISA plate wells.
The TMB ELISA Buffer Kit (Product # 900-T00), sold separately, is recommended to be used in conjunction with this TMB ELISA Development Kit for optimal performance. This buffer kit contains all the necessary components to assay ten 96-well ELISA plates (included) and contains detailed handling instructions.
IL-1 alpha (Interleukin-1 alpha) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 alpha is coded by the IL1A gene and signals through two receptors, IL-1RI and IL-1RII, both of which are shared with IL-1 beta. IL1A is located on the q arm on chromosome 2 at position 13. IL-1 alpha plays an important role in innate host defense by triggering the production of other proinflammatory cytokines in target cells and initiating acute-phase responses. IL-1 alpha activity can be moderated by IL-1 Receptor Antagonist (IL-1RA), a protein produced by many cell types that blocks receptor binding through competitive inhibition. IL-1 alpha is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. Further, IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury and induces apoptosis. The IL1A gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. IL1 alpha regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL-1 alpha can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-1 alpha are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : IL-1A, IL1, IL1-ALPHA, IL1A, IL1F1
Gene ID : (Human) 3552
Gene symbol : IL1A
Protein Aliases : CTLA8, IL17, interleukin 17, Interleukin-17A, IL 1α, IL1α, ILN, Interleukin, Interleukin1 alpha, RP23-160G19.8, IL 1 a, Hematopoietin-1, IL-1 alpha, interleukin 1, alpha, Interleukin-1 alpha, preinterleukin 1 alpha, pro-interleukin-1-alpha
UniProt ID (Human) P01583
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If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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