Invitrogen
Human Calprotectin L1/S100-A8/A9 Complex ELISA Kit
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Product Specifications
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Homogenous (no wash)
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Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
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Detector antibody conjugate
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About This Kit
Human Calprotectin L1/S100-A8/A9 Complex quantitates human Calprotectin L1/S100-A8/A9 Complex in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human Calprotectin L1/S100-A8/A9 Complex.
The S100A8/A9 heterocomplex, also called MRP-8/MRP-14 complex or calprotectin, comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. The S100A8/A9 complex has antibacterial, antifungal, immunomodulating and antiproliferative effects. Besides this it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity, like inflammatory bowel disease. Granulocytes terminate their existence after transmigration through the intestinal wall. Therefore calprotectin is also detectable in feces. Elevated levels of calprotectin have been observed in body fluids such as plasma, saliva, gingival crevicular fluid, stools, and synovial fluid during infection and inflammatory conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : 60B8AG, CAGA, CAGB, CFAG, CGLA, CGLB, CP-10, L1AG, LIAG, MA387, MAC387, MIF, MRP14, MRP8, NIF, P14, P8, S100A8, S100A9
Gene ID : (Human) 6279, (Human) 6280
Gene symbol : S100A8, S100A9
Protein Aliases : AI323541, B8Ag, S100A8/S100A9, calgranulin A, calgranulin B, Calgranulin-A, Calgranulin-B, Calprotectin L1H subunit, Calprotectin L1L subunit, CFAG, Cystic fibrosis antigen, Leukocyte L1 complex heavy chain, Leukocyte L1 complex light chain, Migration inhibitory factor-related protein 14, Migration inhibitory factor-related protein 8, MRP-14, MRP-8, Protein S100-A8, Protein S100-A9, S100 calcium-binding protein A8, S100 calcium-binding protein A8 (calgranulin A), S100 calcium-binding protein A9, S100 calcium-binding protein A9 (calgranulin B), Urinary stone protein band A
UniProt ID (Human) P05109, (Human) P06702
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If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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