Invitrogen
Human CD42b/GPIb-alpha ELISA Kit
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Product Specifications
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Homogenous (no wash)
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Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
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Detector antibody conjugate
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About This Kit
Human CD42b/GPIb-alpha quantitates human CD42b/GPIb-alpha in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human CD42b/GPIb-alpha.
CD42b is a platelet activation marker involved in the process of coagulation as an aggregating factor. It interacts with extracellular matrix as well as with adhesion molecules. CD42b expression and activation seems to be regulated by VEGF and PDGF. CD42b composes together with GPIb beta, GPIX and GPV the GPIb-IX-V receptor complex critical in the process of platelet-rich thrombus formation by tethering the platelet to a thrombogenic surface. CD42b binds to von Willebrand factor (VWF) exposed at a site of vascular injury, as well as to thrombin, coagulation factors XI and XII, high molecular wight kininogen, TSP-1, integrin Mac-1 and P-selectin. The extracellular domain of CD42b by its interactions also contributes to metastasis. Further, CD42b antigen is expressed on platelets and on megakaryocytes in bone marrow. Several polymorphisms and mutations have been described in the CD42b, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GP1BA, GPIbA, GPIbalpha, VWDP
Gene ID : (Human) 2811
Gene symbol : GP1BA
Protein Aliases : Antigen CD42b-alpha, CD42a, GPIB, GPIb alpha, GPIX, GP-IX, MGC34595, Platelet GPIX, CD42b, glycoprotein Ib (platelet), alpha polypeptide, GP-Ib alpha, mutant platelet membrane glycoprotein Ib-alpha, Platelet glycoprotein Ib alpha chain, platelet membrane glycoprotein 1b-alpha subunit, platelet membrane glycoprotein Ib-alpha
UniProt ID (Human) P07359
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If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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