Invitrogen
Human CD 59 ELISA Kit
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Product Specifications
Analytical sensitivity
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Homogenous (no wash)
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Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
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Detector antibody conjugate
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About This Kit
Human CD 59 quantitates human CD 59 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human CD 59.
CD59 (Protectin) is a small (18-20 kDa) GPI-anchored ubiquitously expressed inhibitor of the membrane attack complex (MAC). CD59 is the key regulator that preserves the autologous cells from terminal effector mechanism of the complement cascade. CD59 also associates with C5b-8 complex and counteracts appropriate formation of cytolytic pore within the plasma membrane. Further, CD59 is a low-affinity ligand of human CD2, causes T cell costimulation, and is involved in lymphocyte signal transduction. CD59 is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. Mutations in this gene cause CD59 deficiency, a disease involving hemolytic anemia, thrombosis, and cerebral infarction. Multiple alternatively spliced transcript variants of CD59 have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : 16.3A5, 1F5, CD59, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MAC-IP, MACIF, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20
Gene ID : (Human) 966
Gene symbol : CD59
Protein Aliases : 1F5 antigen, 20 kDa homologous restriction factor, CD59, CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344), CD59 glycoprotein, CD59 molecule, complement regulatory protein, HRF-20, human leukocyte antigen MIC11, Ly-6-like protein, lymphocytic antigen CD59/MEM43, MAC-inhibitory protein, MAC-IP, MACIF, MEM43 antigen, membrane attack complex (MAC) inhibition factor, Membrane attack complex inhibition factor, Membrane inhibitor of reactive lysis, MIRL, Protectin, surface anitgen recognized by monoclonal antibody 16.3A5, T cell-activating protein
UniProt ID (Human) P13987
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If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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