Invitrogen
Human BID ELISA Kit
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Product Specifications
Analytical sensitivity
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Homogenous (no wash)
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Contents
Standard
Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
Wash Buffer
Chromogen
Stop Solution
Adhesive Plate Covers
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Species (tested)
Assay kit format
Detector antibody conjugate
Label or dye
About This Kit
Human BID quantitates human BID in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human BID.
BID is a death agonist that heterodimerizes with either agonist BAX or antagonist BCL2. Bid is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves this encoded protein, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. BID is also a pro-apoptotic member of the Bcl 2 family. BID usually exists in an inactive form in the cytosolic fraction of living cells and becomes cleaved and activated by caspase 8 in response to TNF alpha or Fas ligand. Once BID is cleaved, the C-terminal 15 kDa fragment of BID (p15) translocates onto mitochondria and is sufficient to trigger cytochrome c release, resulting in cell apoptosis. BID serves as a direct molecular link between caspase 8 activation and mitochondrial death machinery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : BID, FP497
Gene ID : (Human) 637
Gene symbol : BID
Protein Aliases : apoptic d, HGNC:1050, MGC15319, MGC42355, OTTHUMP00000196197, apoptic death agonist, BH3-interacting domain death agonist, BID, BID isoform ES(1b), BID isoform L(2), BID isoform Si6, desmocollin type 4, Human BID coding sequence, p22 BID
UniProt ID (Human) P55957
Performance Guarantee
If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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