Invitrogen
Human 2B4/CD244 ELISA Kit
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Product Specifications
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Homogenous (no wash)
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Assay Diluent concentrate
Biotinylated Detection Antibody
SAV-HRP
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Detector antibody conjugate
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About This Kit
Human 2B4/CD244 quantitates human 2B4/CD244 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human 2B4/CD244.
CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoproliferative syndrome. Alternatively spliced transcript variants encoding different isoforms of CD244 have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Gene aliases : 2B4, CD244, NAIL, NKR2B4, Nmrk, SLAMF4
Gene ID : (Human) 51744
Gene symbol : CD244
Protein Aliases : CD244, CD244 molecule, natural killer cell receptor 2B4, h2B4, NAIL, Natural killer cell receptor 2B4, NK cell activation inducing ligand NAIL, NK cell activation-inducing ligand, NK cell type I receptor protein 2B4, NKR Nmrk, NKR2B4, Signaling lymphocytic activation molecule 4, SLAM family member 4, SLAMF4
UniProt ID (Human) Q9BZW8
Performance Guarantee
If an Invitrogen™ immunoassay doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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