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p75NTR Monoclonal Antibody (MC192)

1 Reference
View all (99) NGFR (CD271) antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

OSM00019A-100UG

Applications
Tested Dilution
Publications

Western Blot (WB)

5-15 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

5-15 µg/mL
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

Assay-dependent
-

ELISA (ELISA)

5-15 µg/mL
-

Miscellaneous PubMed (MISC)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

MC192

Immunogen

Nerve growth factor receptor (TNFR superfamily, member 16)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

Affinity chromatography

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

Specificity of this antibody: rat p75NTR.

Target Information

Neurotrophic factors control the survival, differentiation and maintenance of neurons in the peripheral and central nervous systems, and of other neural crest-derived cell types. Developing sympathetic neurons are absolutely dependent upon nerve growth factor (NGF) during the period of target competition in vivo. Antibodies reacting specifically with NGFR p75 are useful tools in the detection and characterization of NGFR p75, to enhance our understanding of a wide range of phenomena in the development, plasticity and repair of the nervous system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CD271; CD271 antigen; Gp80-LNGFR; low affinity nerve growth factor receptor; Low affinity neurotrophin receptor p75NTR; Low-affinity nerve growth factor receptor; Low-affinity nerve growth factor receptor p75NGFR; Low-affinity nerve growth factor receptor p75NGR; nerve growth factor receptor (TNFR superfamily, member 16); nerve growth factor receptor, fast; NGF receptor; p-75; p75 ICD; p75 ntr; TNR16; Tumor necrosis factor receptor superfamily member 16

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Gene Aliases: LNGFR; Ngfr; p75; p75NTR; RNNGFRR; Tnfrsf16

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UniProt ID: (Rat) P07174

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Entrez Gene ID: (Rat) 24596

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Function(s)
beta-amyloid binding death receptor activity neurotrophin TRKA receptor binding protein binding Rab GTPase binding ubiquitin protein ligase binding neurotrophin binding nerve growth factor binding preprotein binding
Process(es)
intracellular protein transport apoptotic process signal transduction axon guidance central nervous system development response to wounding regulation of gene expression positive regulation of cell death negative regulation of neuron projection development programmed cell death detection of temperature stimulus sensory perception of pain nerve development hair follicle morphogenesis positive regulation of myelination positive regulation of synaptic transmission, cholinergic response to lipopolysaccharide circadian regulation of gene expression cellular response to oxidative stress positive regulation of Rho protein signal transduction skeletal muscle cell differentiation negative regulation of fibroblast growth factor receptor signaling pathway positive regulation of odontogenesis of dentin-containing tooth glucose homeostasis positive regulation of apoptotic process positive regulation of MAPK cascade negative regulation of neuron apoptotic process skin development positive regulation of fibroblast proliferation negative regulation of hair follicle development positive regulation of protein kinase B signaling negative regulation of mitochondrial depolarization positive regulation of synaptic transmission, glutamatergic negative regulation of cell death positive regulation of neuron death regulation of reactive oxygen species metabolic process positive regulation of apoptotic signaling pathway regulation of glucose import in response to insulin stimulus
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