Proteintech

cIAP1 Polyclonal Antibody

19 References
View all (18) cIAP1 antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers
cIAP1 Polyclonal Antibody

Product Details

10022-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 14 publications 14 publications

Immunohistochemistry (IHC)

-
View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500
-

Immunocytochemistry (ICC/IF)

1:10-1:100
View 2 publications 2 publications

Not applicable (N/A)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse, Zebrafish

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

cIAP1 Fusion Protein Ag15203 (1-350 aa encoded by BC016174)
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.22 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This BIRC2 antibody (10022-1-AP) can bind both full length (70 kDa) and cleaved form (60 kDa) of the protein.

Immunogen sequence: MHKTASQRL FPGPSYQNIK SIMEDSTILS DWTNSNKQKM KYDFSCELYR MSTYSTFPAG VPVSERSLAR AGFYYTGVND KVKCFCCGLM LDNWKLGDSP IQKHKQLYPS CSFIQNLVSA SLGSTSKNTS PMRNSFAHSL SPTLEHSSLF SGSYSSLSPN PLNSRAVEDI SSSRTNPYSY AMSTEEARFL TYHMWPLTFL SPSELARAGF YYIGPGDRVA CFACGGKLSN WEPKDDAMSE HRRHFPNCPF LENSLETLRF SISNLSMQTH AARMRTFMYW PSSVPVQPEQ LASAGFYYVG RNDDVKCFCC DGGLRCWESG DDPWVEHAKW FPRCEFLIRM KGQEFVDEIQ G (1-350 aa encoded by BC016174)

Target Information

The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. This encoded protein inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: apoptosis inhibitor 1; apoptosis inhibitor 2; baculoviral IAP repeat-containing 2; baculoviral IAP repeat-containing 3; Baculoviral IAP repeat-containing protein 2; C-IAP1; Cellular inhibitor of apoptosis 1; hIAP-2; IAP homolog B; IAP-2; Inhibitor of apoptosis protein 2; mIAP-2; mIAP2; NFR2-TRAF signalling complex protein; RING finger protein 48; RING-type E3 ubiquitin transferase BIRC2; TNFR2-TRAF-signaling complex protein 2

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Gene Aliases: API1; Api2; AW146227; BIRC2; Birc3; c-IAP1; cIAP1; cIAP2; Hiap-2; HIAP1; HIAP2; IAP1; IAP2; mcIAP1; MIAP1; MIAP2; MIHB; MIHC; RNF48

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UniProt ID: (Human) Q13490, (Mouse) Q62210

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Entrez Gene ID: (Human) 329, (Mouse) 11797

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Function(s)
transcription coactivator activity ubiquitin-protein transferase activity protein binding zinc ion binding transferase activity ligase activity cysteine-type endopeptidase inhibitor activity involved in apoptotic process protein N-terminus binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity
Process(es)
protein polyubiquitination response to hypoxia placenta development transcription, DNA-templated regulation of transcription, DNA-templated cellular component disassembly involved in execution phase of apoptosis cell surface receptor signaling pathway I-kappaB kinase/NF-kappaB signaling regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death tumor necrosis factor-mediated signaling pathway regulation of toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway NIK/NF-kappaB signaling regulation of RIG-I signaling pathway regulation of cell proliferation regulation of apoptotic process negative regulation of apoptotic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process regulation of innate immune response response to ethanol regulation of cell differentiation regulation of inflammatory response protein heterooligomerization response to cAMP regulation of cell cycle regulation of necroptotic process necroptotic process regulation of nucleotide-binding oligomerization domain containing signaling pathway mitotic spindle assembly negative regulation of ripoptosome assembly involved in necroptotic process positive regulation of protein K63-linked ubiquitination positive regulation of protein K48-linked ubiquitination positive regulation of protein monoubiquitination inhibition of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity regulation of reactive oxygen species metabolic process apoptotic process protein ubiquitination negative regulation of necroptotic process regulation of nucleic acid-templated transcription
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