Invitrogen

XDH Recombinant Rabbit Monoclonal Antibody (4B7L4)

Name: XDH Recombinant Rabbit Monoclonal Antibody (4B7L4)
Brand: Invitrogen
SKU: MA5-51417

View all (25) XDH antibodies

Datasheet

Protocols

Questions & Answers

Datasheet

Protocols

Questions & Answers

Antibody Testing Data (2)

FIGURE: 1 / 2

XDH Antibody (MA5-51417) in WB

Western blot analysis of XDH in various lysates. Samples were incubated with XDH Recombinant monoclonal antibody (Product # MA5-51417) using a dilution of 1:1,000 followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

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Immunogen image

Immunogen Image XDH Recombinant Rabbit Monoclonal Antibody (4B7L4)

Product Details

MA5-51417

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

ELISA (ELISA)

1 µg/mL

Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4B7L4

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human Xanthine Oxidase (XDH) (NP_000370.2).

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.05% ProClin 300

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

AB_3093923

Product Specific Information

Immunogen sequence: CIIPTKFGIS FTVPFLNQAG ALLHVYTDGS VLLTHGGTEM GQGLHTKMVQ VASRALKIPT SKIYISETST NTVPNTSPTA ASVSADLNGQ AVYAACQTIL K

Target Information

XDH belongs to the group of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines. The enzyme is a homodimer. This protein can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Xanthine dehydrogenase/oxidase; xanthine oxidase; xanthine oxidoreductase; xdh antibody; xdha antibody; xor antibody

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Gene Aliases: Xdh; XO; XOR; Xox-1; Xox1

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UniProt ID: (Rat) P22985, (Mouse) Q00519

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Entrez Gene ID: (Rat) 497811, (Mouse) 22436

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Function(s)

xanthine dehydrogenase activity xanthine oxidase activity iron ion binding UDP-N-acetylmuramate dehydrogenase activity electron carrier activity oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors protein homodimerization activity molybdopterin cofactor binding flavin adenine dinucleotide binding 2 iron, 2 sulfur cluster binding catalytic activity protein binding oxidoreductase activity, acting on CH-OH group of donors molybdenum ion binding metal ion binding iron-sulfur cluster binding

Process(es)

negative regulation of protein phosphorylation negative regulation of endothelial cell proliferation activation of cysteine-type endopeptidase activity involved in apoptotic process lactation xanthine catabolic process response to aluminum ion negative regulation of gene expression regulation of epithelial cell differentiation bone resorption negative regulation of endothelial cell differentiation negative regulation of protein kinase B signaling oxidation-reduction process positive regulation of p38MAPK cascade negative regulation of vascular endothelial growth factor signaling pathway positive regulation of reactive oxygen species metabolic process negative regulation of vasculogenesis

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XDH Recombinant Rabbit Monoclonal Antibody (4B7L4)

XDH Antibody (MA5-51417) in WB

Product Details

MA5-51417

Western Blot (WB)

ELISA (ELISA)

Species Reactivity

Host/Isotype

Expression System

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

RRID

Product Specific Information

Target Information

References (0)

Bioinformatics

Performance Guarantee

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