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Invitrogen
WHSC2 Polyclonal Antibody
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Product Details
PA5-70518
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
Purification
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RRID
Product Specific Information
This target displays homology in the following species: Cow: 85%; Human: 100%; Mouse: 100%; Pig: 78%; Rat: 100%
Target Information
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: FLJ10442; FLJ25112; mWHSC2; Negative elongation factor A; NELF-A; Wolf-Hirschhorn syndrome candidate 2 homolog
Gene Aliases: Nelfa; Whsc2; Whsc2h
UniProt ID: (Mouse) Q8BG30
Entrez Gene ID: (Mouse) 24116
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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