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Invitrogen
VE-cadherin Monoclonal Antibody (3D5C7)
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Product Details
MA5-17050
Species Reactivity
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Conjugate
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Product Specific Information
MA5-17050 targets CDH5 in FACS, indirect ELISA, and WB applications and shows reactivity with Human and Rat samples.
The MA5-17050 immunogen is purified recombinant fragment of human CDH5 (amino acids: 29-223 ) expressed in E. Coli.
MA5-17050 detects CDH5 which has a predicted molecular weight of approximately 87.5kDa.
Target Information
VE-cadherin is a member of the cadherin superfamily that is located in a six-cadherin cluster in a region on the long arm of chromosome 16 and is involved in loss of heterozygosity events in breast and prostate cancer. VE-cadherin protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classic cadherin by imparting to cells the ability to adhere in a homophilic manner, VE-cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. An alternative splice variant has been described but the full length sequence of VE-cadherin has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 7B4 antigen; cadherin 5, type 2 (vascular endothelium); cadherin 5, type 2, VE-cadherin (vascular epithelium); Cadherin-5; CD144; cd144 antigen; endothelial-specific cadherin; Vascular endothelial cadherin; VE-cadherin
Gene Aliases: 7B4; CD144; CDH5
UniProt ID: (Human) P33151
Entrez Gene ID: (Human) 1003, (Rat) 307618
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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