Invitrogen

Tyrosine Hydroxylase Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers
Tyrosine Hydroxylase Polyclonal Antibody

Product Details

PA5-18372

Applications
Tested Dilution
Publications

Western Blot (WB)

0.5 µg/mL
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1:1,000-1:10,000
-

Immunocytochemistry (ICC/IF)

1:100
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Goat / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide sequence (VQDELDTLAHAL) corresponding to the C-terminus amino acids of TH (aa 513-525).
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Ammonium sulfate precipitation

Storage buffer

TBS, pH 7.3, with 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10979872

Product Specific Information

This antibody is predicted to react with canine and rat based on sequence homology.

This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.

Target Information

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: dystonia 14; EC 1.14.16.2; HGNC:11782; TH; TH isoform 3; TH isoform a; TH-4; TY3H; TYH antibody; Tyrosine 3-hydroxylase; Tyrosine 3-monooxygenase

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Gene Aliases: DYT14; DYT5b; TH; TYH

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UniProt ID: (Human) P07101

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Entrez Gene ID: (Human) 7054

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Function(s)
tyrosine 3-monooxygenase activity protein binding ferrous iron binding ferric iron binding amino acid binding oxygen binding enzyme binding protein domain specific binding tetrahydrobiopterin binding dopamine binding
Process(es)
response to hypoxia synaptic transmission, dopaminergic response to amphetamine heart morphogenesis dopamine biosynthetic process from tyrosine fatty acid metabolic process sphingolipid metabolic process heart development visual perception sensory perception of sound learning memory mating behavior locomotory behavior regulation of heart contraction response to water deprivation response to light stimulus response to herbicide response to salt stress anatomical structure morphogenesis organ morphogenesis response to zinc ion multicellular organism aging response to activity aminergic neurotransmitter loading into synaptic vesicle glycoside metabolic process phthalate metabolic process cerebral cortex development response to nutrient levels response to estradiol response to lipopolysaccharide isoquinoline alkaloid metabolic process social behavior cellular response to drug response to isolation stress response to immobilization stress neurotransmitter biosynthetic process terpene metabolic process dopamine biosynthetic process epinephrine biosynthetic process norepinephrine biosynthetic process catecholamine biosynthetic process eye photoreceptor cell development circadian sleep/wake cycle eating behavior response to peptide hormone pigmentation response to ethanol response to ether response to pyrethroid embryonic camera-type eye morphogenesis response to corticosterone response to electrical stimulus phytoalexin metabolic process oxidation-reduction process cellular response to manganese ion cellular response to nicotine cellular response to glucose stimulus cellular response to growth factor stimulus
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