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  • TrkA/TrkB Antibodies

Invitrogen

TrkA/TrkB Polyclonal Antibody

View all (6) TrkA/TrkB antibodies

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Datasheet
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Datasheet
Protocols
Questions & Answers

Cite TrkA/TrkB Polyclonal Antibody

  • Antibody Testing Data (1)
TrkA/TrkB Antibody in Western Blot (WB)
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TrkA/TrkB Antibody in Western Blot (WB)
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TrkA/TrkB Antibody (PA5-105255) in WB

Western blot analysis of TrkA/TrkB in Jurkat cell lysate (left lane: treated with blocking peptide). Samples were incubated with TrkA/TrkB polyclonal antibody (Product # PA5-105255). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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TrkA/TrkB Antibody in Western Blot (WB)
TrkA/TrkB Polyclonal Antibody

Product Details

PA5-105255

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NTRK1(Accession P04629), corresponding to amino acid residues R771-G796.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2816720

Product Specific Information

Antibody detects endogenous levels of total TrkA /TrkB.

Target Information

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BDNF-tropomyosine receptor kinase B; BDNF/NT-3 growth factors receptor; gp140trk; GP145-TrkB; GP145-TrkB/GP95-TrkB; High affinity nerve growth factor receptor; neural receptor protein-tyrosine kinase (trkB); Neurotrophic tyrosine kinase receptor type 1; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 1; neurotrophic tyrosine kinase, receptor, type 2; neurotrophic tyrosine receptor kinase type 2; Oncogene TRK; p140-TrkA; Slow nerve growth factor receptor; trk; Trk-A; Trk-B; TRK1-transforming tyrosine kinase protein; TrkA neurotrophin receptor; trkA proto-oncogene receptor; TrkB tyrosine kinase; Tropomyosin-related kinase A; Tropomyosin-related kinase B; Tyrosine kinase receptor; Tyrosine kinase receptor A; tyrosine kinase receptor B

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Gene Aliases: C80751; GP145-TrkB; GP145-TrkB/GP95-TrkB; MTC; NTRK1; NTRK2; p140-TrkA; RATTRKB1; Tkr; Tkrb; TRK; Trk-A; trk-B; TRK1; TRKA; TRKB; TRKB1

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UniProt ID: (Human) P04629, (Human) Q16620, (Mouse) Q3UFB7, (Rat) P35739, (Mouse) P15209, (Rat) Q63604

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Entrez Gene ID: (Human) 4914, (Human) 4915, (Mouse) 18211, (Rat) 59109, (Mouse) 18212, (Rat) 25054

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Function(s)
transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase binding protein homodimerization activity neurotrophin binding nerve growth factor binding receptor tyrosine kinase binding brain-derived neurotrophic factor binding brain-derived neurotrophic factor-activated receptor activity nucleotide binding protein kinase activity protein tyrosine kinase activity neurotrophin receptor activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups ephrin receptor binding
Process(es)
protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development axon guidance learning or memory programmed cell death involved in cell development response to activity phosphorylation peptidyl-tyrosine phosphorylation sensory perception of pain cell differentiation B cell differentiation response to nutrient levels response to nicotine nerve growth factor signaling pathway mechanoreceptor differentiation response to drug positive regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of angiogenesis protein autophosphorylation neurotrophin TRK receptor signaling pathway sympathetic nervous system development detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity response to electrical stimulus positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic Sertoli cell development innervation axonogenesis involved in innervation behavioral response to formalin induced pain cellular response to nicotine cellular response to growth factor stimulus negative regulation of neuron death cellular response to nerve growth factor stimulus vasculogenesis neuron migration neuromuscular junction development learning long-term memory feeding behavior positive regulation of cell proliferation positive regulation of gene expression positive regulation of neuron projection development glutamate secretion positive regulation of phosphatidylinositol 3-kinase signaling regulation of metabolic process central nervous system neuron development cerebral cortex development neuron differentiation brain-derived neurotrophic factor receptor signaling pathway positive regulation of peptidyl-serine phosphorylation calcium-mediated signaling using intracellular calcium source neurotrophin signaling pathway regulation of GTPase activity regulation of MAPK cascade positive regulation of MAPK cascade retinal rod cell development regulation of neurotransmitter secretion oligodendrocyte differentiation peripheral nervous system neuron development positive regulation of axonogenesis regulation of dendrite development regulation of protein kinase B signaling retina development in camera-type eye long-term synaptic potentiation cellular response to amino acid stimulus positive regulation of glucocorticoid receptor signaling pathway negative regulation of anoikis positive regulation of protein phosphorylation inflammatory response aging circadian rhythm response to light stimulus response to auditory stimulus cellular response to tumor necrosis factor cellular response to brain-derived neurotrophic factor stimulus negative regulation of cell proliferation response to radiation olfactory nerve development response to ethanol positive regulation of Ras protein signal transduction response to axon injury response to hydrostatic pressure positive regulation of ERK1 and ERK2 cascade activation of MAPKK activity microtubule-based movement positive regulation of GTPase activity ephrin receptor signaling pathway phosphatidylinositol-mediated signaling
It has to be done as per old AB suggested Products section.
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