Invitrogen

TrkA Monoclonal Antibody (185CT47.6.1)

View all (49) TrkA antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-37489

Applications
Tested Dilution
Publications

Western Blot (WB)

1:100-1:500
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

185CT47.6.1

Immunogen

NTRK1 recombinant protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Protein G

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897422

Target Information

NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: DKFZp781I14186; EC 2.7.10.1; High affinity nerve growth factor receptor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1

View more View less

Gene Aliases: C80751; Ntrk1; Tkr; trk; TrkA

View more View less

UniProt ID: (Mouse) Q3UFB7

View more View less

Entrez Gene ID: (Mouse) 18211

View more View less

Function(s)
nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity neurotrophin receptor activity neurotrophin p75 receptor binding protein binding ATP binding nerve growth factor receptor activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups kinase binding protein homodimerization activity ephrin receptor binding nerve growth factor binding
Process(es)
protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development nervous system development axon guidance learning or memory programmed cell death involved in cell development response to activity phosphorylation peptidyl-tyrosine phosphorylation sensory perception of pain cell differentiation B cell differentiation response to nutrient levels response to nicotine nerve growth factor signaling pathway mechanoreceptor differentiation response to drug positive regulation of programmed cell death negative regulation of neuron apoptotic process positive regulation of angiogenesis protein autophosphorylation neurotrophin TRK receptor signaling pathway sympathetic nervous system development detection of temperature stimulus involved in sensory perception of pain detection of mechanical stimulus involved in sensory perception of pain positive regulation of NF-kappaB transcription factor activity response to electrical stimulus positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic Sertoli cell development innervation axonogenesis involved in innervation behavioral response to formalin induced pain cellular response to nicotine cellular response to growth factor stimulus negative regulation of neuron death cellular response to nerve growth factor stimulus
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support