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NeoBiotechnologies
Transglutaminase II (TGM2) Monoclonal Antibody (TGM2/419)
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Product Details
7052-MSM1-P1ABX
Species Reactivity
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Target Information
Transglutaminase (TGase) catalyses the crosslink of proteins by forming e-(g-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. In mammals, eight distinct TGase isoenzymes have been identified. Tissue transglutaminase (tTGase), also known as TGase 2, has four distinct domains: N-terminal b-sandwich, catalytic core and two C-terminal b-barrel domains. tTGase may have a role in cell death, cell proliferation, cell differentiation, and receptor-mediated endocytosis. In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Ab peptide, b-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: C polypeptide; C polypeptide, protein-glutamine-gamma-glutamyltransferase; Erythrocyte transglutaminase; G alpha h; G(h); G-ALPHA-h; GNAH; Heart G alpha(h); hhG alpha(h); Isopeptidase TGM2; Protein G alpha(h); Protein G(h); Protein-glutamine deamidase TGM2; Protein-glutamine dopaminyltransferase TGM2; Protein-glutamine gamma-glutamyltransferase 2; Protein-glutamine histaminyltransferase TGM2; Protein-glutamine noradrenalinyltransferase TGM2; Protein-glutamine serotonyltransferase TGM2; protein-glutamine-gamma-glutamyltransferase; RP5-1054A22.2; TG C; TG(C); TG2; TGase 2; TGase C; TGase H; TGase II; TGase-2; TGase-H; TGC; Tissue transglutaminase; Tissue type transglutaminase; tissue-type transglutaminase; transglutaminase 2; Transglutaminase 2 C polypeptide; transglutaminase 2, C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase II; Transglutaminase-2; tTG
Gene Aliases: G[a]h; TG(C); TG2; TGase2; TgaseII; TGC; TGM2; tTG; tTGas
UniProt ID: (Human) P21980, (Rat) Q9WVJ6, (Mouse) P21981
Entrez Gene ID: (Rabbit) 100352148, (Human) 7052, (Rat) 56083, (Mouse) 21817
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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