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Invitrogen
Transferrin Monoclonal Antibody (HTF-14)
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Product Details
MA1-19013
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
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Purification
Storage buffer
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RRID
Product Specific Information
This antibody recognizes an epitope located in the N-terminal domain of human serum transferrin, a 77 kDa single polypeptide chain glycoprotein (member of the iron binding family of proteins). It is synthesized in the liver and consists of two domains each having a high affinity reversible binding site for Fe3+.
This antibody will not cross-react with sheep, canine, equine or bovine.
A suggested positive control is placental tissue.
Western Blot: non-reducing conditions; Functional Application: Blocking.
Target Information
Transferrins (Tf) are an approximately 80kDa blood plasma glycoprotein synthesized by the liver. They are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Transferrin is the primary blood iron transport protein and under normal conditions; approximately one-third of total blood transferrin contains bound iron. Measurement of blood transferrin levels can be used as an indicator for blood iron-carrying capacity and abnormalities of iron metabolism such as anaemia, iron overload and haemochromatosis.Serum transferrin may also have a further role in stimulating cell proliferation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: Beta-1 metal-binding globulin; DKFZp781D0156; epididymis secretory sperm binding protein Li 71p; Inhibitor of carbonic anhydrase; Serotransferrin; Siderophilin; transferin; Transferrin
Gene Aliases: HEL-S-71p; ICA; INHCA; PICA; PRO1400; PRO1557; PRO2086; TF; TFQTL1
UniProt ID: (Pig) Q29545, (Human) P02787, (Rabbit) P19134
Entrez Gene ID: (Pig) 396845, (Pig) 396996, (Human) 7018, (Rabbit) 100009267
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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