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Invitrogen
Thioredoxin 2 Recombinant Rabbit Monoclonal Antibody (9V7J1)
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Product Details
MA5-35514
Species Reactivity
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Product Specific Information
Immunogen sequence: GPDFQDRVVN SETPVVVDFH AQWCGPCKIL GPRLEKMVAK QHGKVVMAKV DIDDHTDLAI EYEVSAVPTV LAMKNGDVVD KFVGIKDEDQ LEAFLKKLIG
Target Information
Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cystein residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53, NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: mitochondrial thioredoxin; mt-Trx; MTRX; thioredoxin nuclear gene encoding mitochondrial protein; Thioredoxin, mitochondrial; Thioredoxin-2; Thioredoxin2; TRX-2
Gene Aliases: 2510006J11Rik; AI788873; COXPD29; MT-TRX; MTRX; TRX2; TXN2
UniProt ID: (Human) Q99757, (Mouse) P97493, (Rat) P97615
Entrez Gene ID: (Human) 25828, (Mouse) 56551, (Rat) 79462
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