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  • TYRO3 Antibodies

Abnova

TYRO3 Monoclonal Antibody (4F6)

View all (41) TYRO3 antibodies

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Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers

Cite TYRO3 Monoclonal Antibody (4F6)

  • Antibody Testing Data (3)
TYRO3 Antibody in ELISA (ELISA)
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TYRO3 Antibody in ELISA (ELISA)
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TYRO3 Antibody (H00007301-M05) in ELISA

Detection limit for recombinant GST tagged TYRO3 is approximately 0.1 ng/mL as a capture antibody. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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TYRO3 Antibody in Western Blot (WB)
TYRO3 Antibody in Western Blot (WB)
TYRO3 Antibody in ELISA (ELISA)
TYRO3 Monoclonal Antibody (4F6)

Product Details

H00007301-M05

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

ELISA (ELISA)

0.1 ng/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

4F6

Immunogen

TYRO3 (AAH49368, 50 a.a. approximately 150 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: VKLTVSQGQP VRLNCSVEGM EEPDIQWVKD GAVVQNLDQL YIPVSEQHWI GFLSLKSVER SDAGRYWCQV EDGGETEISQ PVWLTVEGVP FFTVEPKDLA V

Target Information

TYRO3 (tyrosine-protein kinase receptor TYRO3) is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. It regulates many physiological processes including cell survival, migration, and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by a ligand, TYRO3 plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation, signal transduction, cell adhesion. and cytoskeleton reorganization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: FLJ16467; soluble tyro 3; soluble tyro3; styro 3; styro3; tyro 3; Tyrosine-protein kinase BYK; Tyrosine-protein kinase DTK; Tyrosine-protein kinase receptor TYRO3; Tyrosine-protein kinase RSE; Tyrosine-protein kinase SKY; Tyrosine-protein kinase TIF

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Gene Aliases: BYK; DTK; Etk-2; Rek; RSE; SKY; TIF; TYRO3

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UniProt ID: (Human) Q06418

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Entrez Gene ID: (Human) 7301

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Function(s)
virus receptor activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity protein binding ATP binding phosphatidylinositol 3-kinase binding protein heterodimerization activity
Process(es)
natural killer cell differentiation cell adhesion signal transduction spermatogenesis phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation forebrain cell migration signal transduction by protein phosphorylation platelet activation secretion by cell negative regulation of toll-like receptor signaling pathway substrate adhesion-dependent cell spreading ovulation cycle apoptotic cell clearance protein kinase B signaling negative regulation of neuron apoptotic process negative regulation of innate immune response viral entry into host cell protein autophosphorylation negative regulation of inflammatory response negative regulation of lymphocyte activation vagina development neuron cellular homeostasis platelet aggregation
It has to be done as per old AB suggested Products section.
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