NeoBiotechnologies

TTF-1/NKX2.1 (Thyroid and Lung Epithelial Marker) Monoclonal Antibody (NX2.1/9031)

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Datasheet
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Datasheet
Protocols
Questions & Answers
TTF-1/NKX2.1 (Thyroid and Lung Epithelial Marker) Monoclonal Antibody (NX2.1/9031)

Product Details

7080-MSM21-P1

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

NX2.1/9031

Immunogen

Recombinant fragment (around aa1-200) of human TTF-1 protein.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

Protein A/G

Storage buffer

PBS with 0.05% BSA

Contains

0.05% sodium azide

Storage conditions

4°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Positive Control:Normal thyroid or lung.

Cellular Location: Nucleus.

Target Information

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK-2 homolog A; T/EBP; Thyroid nuclear factor 1; Thyroid transcription factor 1; Thyroid-specific enhancer-binding protein; TTF-1; TTF1

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Gene Aliases: BCH; BHC; NK-2; NKX2-1; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1

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UniProt ID: (Human) P43699

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Entrez Gene ID: (Human) 7080

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II regulatory region DNA binding core promoter binding intronic transcription regulatory region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding enzyme binding transcription regulatory region DNA binding intronic transcription regulatory region DNA binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter neuron migration regulation of blood volume by renin-angiotensin transcription, DNA-templated phospholipid metabolic process axon guidance brain development endoderm development locomotory behavior feeding behavior response to hormone positive regulation of gene expression negative regulation of epithelial to mesenchymal transition globus pallidus development hippocampus development cerebral cortex cell migration forebrain dorsal/ventral pattern formation forebrain neuron fate commitment cerebral cortex GABAergic interneuron differentiation pituitary gland development lung development negative regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway thyroid gland development forebrain development developmental induction response to lipopolysaccharide Leydig cell differentiation hyperosmotic salinity response positive regulation of circadian rhythm response to ethanol negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter development of primary female sexual characteristics rhythmic process anatomical structure formation involved in morphogenesis oligodendrocyte differentiation lung saccule development epithelial tube branching involved in lung morphogenesis Clara cell differentiation Type II pneumocyte differentiation
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