NeoBiotechnologies

TTF-1/NKX2.1 (Thyroid and Lung Epithelial Marker) Monoclonal Antibody (NX2.1/690)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

7080-MSM2-P1ABX

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent
-

Immunohistochemistry (PFA fixed) (IHC (PFA))

1-2 µg/mL
-

Immunocytochemistry (ICC/IF)

0.5-1 µg/mL
-

Flow Cytometry (Flow)

0.5-1 µg/10^6 cells
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

NX2.1/690

Immunogen

Recombinant human TTF-1 protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Homeobox protein NK-2 homolog A; Homeobox protein Nkx-2.1; NK-2 homolog A; T/EBP; Thyroid nuclear factor 1; Thyroid transcription factor 1; thyroid transcription factor 1 TTF-1 NK-2; Thyroid-specific enhancer-binding protein; tinman; TTF-1; TTF1

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Gene Aliases: AV026640; BCH; BHC; NK-2; Nkx-2.1; NKX2-1; NKX2.1; NKX2A; NMTC1; T/EBP; TEBP; TITF1; TTF-1; TTF1

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UniProt ID: (Human) P43699, (Mouse) P50220

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Entrez Gene ID: (Human) 7080, (Mouse) 21869, (Rat) 25628

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II regulatory region DNA binding core promoter binding intronic transcription regulatory region sequence-specific DNA binding DNA binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding protein binding enzyme binding transcription regulatory region DNA binding intronic transcription regulatory region DNA binding transcription factor binding sequence-specific DNA binding transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter neuron migration regulation of blood volume by renin-angiotensin transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter phospholipid metabolic process pattern specification process axon guidance brain development endoderm development locomotory behavior feeding behavior organ morphogenesis positive regulation of gene expression negative regulation of epithelial to mesenchymal transition telencephalon development globus pallidus development hippocampus development cerebral cortex cell migration forebrain dorsal/ventral pattern formation forebrain neuron fate commitment forebrain neuron differentiation cerebral cortex GABAergic interneuron differentiation cerebral cortex neuron differentiation pituitary gland development telencephalon cell migration lung development negative regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway thyroid gland development developmental induction response to lipopolysaccharide Leydig cell differentiation hyperosmotic salinity response menarche positive regulation of circadian rhythm negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter rhythmic process anatomical structure formation involved in morphogenesis neuron fate commitment oligodendrocyte differentiation lung saccule development Clara cell differentiation Type II pneumocyte differentiation response to hormone forebrain development response to ethanol development of primary female sexual characteristics epithelial tube branching involved in lung morphogenesis circadian rhythm
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