Proteintech

TSPO Monoclonal Antibody (1D1F12)

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Datasheet
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Datasheet
Protocols
Questions & Answers
TSPO Monoclonal Antibody (1D1F12)

Product Details

68137-1-IG

Applications
Tested Dilution
Publications

Western Blot (WB)

1:2,000-1:16,000
-

Immunocytochemistry (ICC/IF)

1:400-1:1,600
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgM

Class

Monoclonal

Type

Antibody

Clone

1D1F12

Immunogen

Recombinant protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Caprylic acid precipitation, Ammonium sulfate precipitation

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

Immunogen sequence: MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG PVWGTLYSAM GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF GARQMGWALV DLLLVSGAAA ATTVAWYQVS PLAARLLYPY LAWLAFATTL NYCVWRDNHG WHGGRRLPE

Target Information

Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Benzodiazepin receptor (peripheral); benzodiazepine peripheral binding site; benzodiazepine receptor, peripheral; isoquinoline-binding protein; Mitochondrial benzodiazepine receptor; OTTHUMP00000028891; PBR; Peripheral-type benzodiazepine receptor; PKBS; Translocator protein; translocator protein (18kDa)

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Gene Aliases: BPBS; BZRP; DBI; IBP; MBR; mDRC; PBR; PBS; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; TSPO; Tspo1

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UniProt ID: (Human) P30536, (Rat) P16257, (Mouse) P50637

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Entrez Gene ID: (Human) 706, (Rat) 24230, (Mouse) 12257

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Function(s)
androgen binding protein binding benzodiazepine receptor activity cholesterol binding ion channel binding
Process(es)
steroid biosynthetic process ion transport chloride transport lipid transport chemical synaptic transmission aging glial cell migration response to manganese ion response to vitamin B1 positive regulation of necrotic cell death peripheral nervous system axon regeneration adrenal gland development response to progesterone negative regulation of tumor necrosis factor production response to testosterone response to drug positive regulation of apoptotic process negative regulation of nitric oxide biosynthetic process response to pain behavioral response to pain response to axon injury regulation of steroid biosynthetic process positive regulation of mitochondrial depolarization positive regulation of calcium ion transport contact inhibition positive regulation of glial cell proliferation negative regulation of glial cell proliferation cellular response to lipopolysaccharide cellular response to zinc ion cellular hypotonic response positive regulation of reactive oxygen species metabolic process transport signal transduction protein targeting to mitochondrion heme biosynthetic process anion transport apoptotic process steroid metabolic process cell proliferation negative regulation of protein ubiquitination regulation of cholesterol transport maintenance of protein location in mitochondrion negative regulation of mitophagy negative regulation of ATP metabolic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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