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  • Primary Antibodies ›
  • TSH Receptor Antibodies

Invitrogen

TSH Receptor Polyclonal Antibody

View all (26) TSH Receptor antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Cite TSH Receptor Polyclonal Antibody

  • Antibody Testing Data (4)
TSH Receptor Antibody in Immunocytochemistry (ICC/IF)
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TSH Receptor Antibody in Immunocytochemistry (ICC/IF)
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TSH Receptor Antibody (PA5-116082) in ICC/IF

Immunocytochemistry analysis of TSH Receptor in HeLa cells. Samples were treated with PFA, permeabilized in 0.1% Triton X-100, blocked in 10% serum (45 min at 25°C), and incubated with polyclonal antibody (Product # PA5-116082) at a dilution of 1:200 (1 hr at 37°C). Secondary staining was applied with mouse anti-beta tubulin; AlexaFluor 594 conjugated goat anti-rabbit IgG (Red); AlexaFluor 88 conjugated goa... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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TSH Receptor Antibody in Immunocytochemistry (ICC/IF)
TSH Receptor Antibody in Immunohistochemistry (Paraffin) (IHC (P))
TSH Receptor Antibody in Western Blot (WB)
TSH Receptor Antibody in Western Blot (WB)
TSH Receptor Polyclonal Antibody

Product Details

PA5-116082

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human TSHR(Accession P16473), corresponding to amino acid residues Q379-L429.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2900716

Product Specific Information

Antibody detects endogenous levels of total TSHR.

Target Information

TSH Receptor gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: MGC141920; seven transmembrane helix receptor; thyroid stimulating hormone receptor, isoform 2; Thyroid-stimulating hormone receptor; Thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSH-R

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Gene Aliases: AI481368; CHNG1; hTSHR-I; hypothroid; hyt; LGR3; pet; TSHR

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UniProt ID: (Human) P16473, (Mouse) P47750

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Entrez Gene ID: (Human) 7253, (Mouse) 22095

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Function(s)
thyroid-stimulating hormone receptor activity protein binding G-protein coupled peptide receptor activity signal transducer activity G-protein coupled receptor activity protein-hormone receptor activity
Process(es)
signal transduction G-protein coupled receptor signaling pathway adenylate cyclase-activating G-protein coupled receptor signaling pathway activation of adenylate cyclase activity positive regulation of cell proliferation adult locomotory behavior hormone-mediated signaling pathway B cell differentiation thyroid-stimulating hormone signaling pathway regulation of locomotion positive regulation of multicellular organism growth inner ear receptor cell development inner ear receptor stereocilium organization dopaminergic neuron differentiation cochlea morphogenesis G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger cell-cell signaling nervous system development
It has to be done as per old AB suggested Products section.
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