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Invitrogen
TREX2 Polyclonal Antibody
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Product Details
PA5-20666
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
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Concentration
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Product Specific Information
A suggested positive control is rat liver tissue lysate.
PA5-20666 can be used with blocking peptide PEP-0786.
Target Information
TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: 3'-5' exonuclease TREX2; 3'-5' exonuclease TREX2 long form; Three prime repair exonuclease 2
Gene Aliases: RGD1562245; TREX2
UniProt ID: (Human) Q9BQ50, (Mouse) Q9R1A9
Entrez Gene ID: (Human) 11219, (Rat) 309275, (Mouse) 24102
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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