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Proteintech
TRDN Polyclonal Antibody
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Product Details
26607-1-AP
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
Product Specific Information
Immunogen sequence: NFSASSIAKI GSDPLKLVRD AMEETTDWIY GFFSLLSDII SSEDEEDDDG DEDSDKGEID EPPLRKKEIH KDKTEKQEKP ERKIQTKVTH KEKEKGKEKV REKEKPEKKA THKEKIEKKE KPETKTVAKE QKKAKTAEKS EEKTKKEVKG GKQEKVKQTA AKVKEVQKTP SKPKEKEDKE KAAVSKHEQK GQSPAIPPPL PTEQASRPTP ASPALEGKY
Target Information
The junction between the transverse tubules (T-tubules) and the sarcoplasmic reticulum (SR) of skeletal muscle is called the triad. At the triad, dihydropyridine receptors (DHPR's) of the T-tubule serve as voltage sensors in excitation-contraction coupling, while ryanodine receptors (RyR's), the calcium release channels, exist in the membrane of the terminal cisternae of the SR. It is thought that during slow phase depolarization of the T-tubule, a third protein, triadin (MW 95 kDa) transmits electrochemical signals to the SR through direct interaction with both DHPR's and RyR's. Though its exact role in this signaling process is unclear, triadin has been shown to co-localize with both DHPR and RYR at the junctional face of the terminal cisternae.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: cardiac triadin; Triadin; triadin 1; triadin 32 kDa (TRISK 32); triadin 49 kDa (TRISK 49); triadin 95
Gene Aliases: 2310045H21Rik; CPVT5; EG432451; TDN; TRDN; TRISK
UniProt ID: (Human) Q13061, (Rat) Q9QX75, (Mouse) E9Q9K5
Entrez Gene ID: (Human) 10345, (Rat) 59299, (Mouse) 76757
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