Invitrogen

TRAF2 Monoclonal Antibody (214CT16.3.4)

Advanced Verification
View all (32) TRAF2 antibodies

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}

{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-37507

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

Immunocytochemistry (ICC/IF)

1:10-1:50
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

214CT16.3.4

Immunogen

TRAF2 recombinant protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Protein G

Storage buffer

PBS, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2897439

Target Information

Tumor necrosis factor (TNF) receptor associated factors (TRAFs) were initially discovered as adaptor proteins that link the TNF receptor superfamily to signaling pathways and are thus important regulators of cell death and cellular response to stress. TRAF proteins share a homology region that allows them to bind to cell receptors and other TRAF proteins, causing the activation of different signal cascades depending on the TRAFs involved. For example, TRAF2 and TRAF3 directly bind to the CD40, a NF receptor superfamily member involved in inducing B cell immunity, and are critical for NF-kappa-B activation in mouse B lymphocytes. TRAF2 along with TRAF6 has also been shown to be required for CD40 signaling in nonhemopoietic cells. TRAF2 also interacts with the TRFR superfamily member lymphotoxin-beta receptor (LTbetaR) in association with TRAF3 and the apoptosis inhibitors cIAP1 and Smac.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: E3 ubiquitin-protein ligase TRAF2; OTTHUMP00000064745; RING-type E3 ubiquitin transferase TRAF2; TNF receptor-associated factor 2; tumor necrosis factor type 2 receptor associated protein 3; Tumor necrosis factor type 2 receptor-associated protein 3

View more View less

Gene Aliases: MGC:45012; TRAF2; TRAP; TRAP3

View more View less

UniProt ID: (Human) Q12933

View more View less

Entrez Gene ID: (Human) 7186

View more View less

Function(s)
ubiquitin-protein transferase activity signal transducer activity tumor necrosis factor receptor binding CD40 receptor binding protein binding zinc ion binding ligase activity enzyme binding protein kinase binding protein phosphatase binding mitogen-activated protein kinase kinase kinase binding ubiquitin protein ligase binding thioesterase binding protein complex binding identical protein binding sphingolipid binding
Process(es)
positive regulation of T cell cytokine production protein complex assembly activation of cysteine-type endopeptidase activity involved in apoptotic process signal transduction I-kappaB kinase/NF-kappaB signaling activation of NF-kappaB-inducing kinase activity regulation of tumor necrosis factor-mediated signaling pathway regulation of necrotic cell death protein catabolic process positive regulation of interleukin-2 production tumor necrosis factor-mediated signaling pathway negative regulation of glial cell apoptotic process response to endoplasmic reticulum stress regulation of apoptotic process positive regulation of JUN kinase activity cellular protein complex assembly positive regulation of T cell activation regulation of immunoglobulin secretion positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of NF-kappaB transcription factor activity protein heterooligomerization protein autoubiquitination intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress protein homotrimerization protein K63-linked ubiquitination death-inducing signaling complex assembly cellular response to nitric oxide positive regulation of protein homodimerization activity activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway programmed necrotic cell death negative regulation of neuron death regulation of extrinsic apoptotic signaling pathway via death domain receptors negative regulation of extrinsic apoptotic signaling pathway via death domain receptors positive regulation of tumor necrosis factor-mediated signaling pathway positive regulation of I-kappaB phosphorylation positive regulation of extrinsic apoptotic signaling pathway
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support