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Invitrogen
TOPORS Polyclonal Antibody
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Product Details
PA5-66342
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
RRID
Product Specific Information
Immunogen sequence: GGATCQIQGVQ TNDDLNNDSD DSSDNCVIVG FVKPLAERTP ELVELSSDSE DLGSYEKMET VKTQEQEQSY SSGDSDVSRC SSPHSVLGKD EQINKGHCDS STRIKSKKEE KRSTSLSSPR NL
Highest antigen sequence identity to the following orthologs - mouse 85%, rat 86%.
Target Information
Functions as an E3 ubiquitin-protein ligase and as an E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA damage-induced cell death through IKBKE sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: E3 ubiquitin-protein ligase Topors; p53-binding protein 3; RING-type E3 ubiquitin transferase Topors; SUMO1-protein E3 ligase Topors; topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase; Topoisomerase I-binding arginine/serine-rich protein; Topoisomerase I-binding RING finger protein; Tumor suppressor p53-binding protein 3
Gene Aliases: LUN; P53BP3; RP31; TOPORS; TP53BPL
UniProt ID: (Human) Q9NS56
Entrez Gene ID: (Human) 10210
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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