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Invitrogen
TOLLIP Polyclonal Antibody
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Product Details
PA5-83431
Species Reactivity
Host/Isotype
Class
Type
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
Contains
Storage conditions
Shipping conditions
RRID
Product Specific Information
Immunogen sequence: VEDKWYSLSG RQGDDKEGMI NLVMSYALLP AAMVMPPQPV VLMPTVYQQG VGYVPITGMP AVCSPGMVPV ALPPAAVNAQ PRCSEEDLKA
Target Information
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: adapter protein; FLJ33531; Toll-interacting protein; tollip {ECO:0000312|EMBL:AAI33068.1}
Gene Aliases: IL-1RAcPIP; TOLLIP
UniProt ID: (Human) Q9H0E2, (Rat) A2RUW1
Entrez Gene ID: (Human) 54472, (Rat) 361677
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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