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Invitrogen
TOLLIP Polyclonal Antibody
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FIGURE: 1 / 6
TOLLIP Antibody (PA5-30747) in ICC/IF
Product Details
PA5-30747
Species Reactivity
Published species
Host/Isotype
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Type
Immunogen
Conjugate
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RRID
Product Specific Information
Recommended positive controls: NT2D1, IMR32, U87-MG, MCF-7, CL1-5.
Predicted reactivity: Mouse (90%), Rat (90%), Pig (88%), Chicken (87%), Rhesus Monkey (100%), Bovine (89%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules to activate various kinases and transcription factors so the organism can respond to potential infection. These adaptor molecules include TOLLIP, MyD88, and TRIF. TOLLIP associates directly with TLR2 and TLR 4, acting as an inhibitor to TLR activation. This negative regulation of TLR signaling may serve to limit the production of proinflammatory mediators during infection and inflammation.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adapter protein; FLJ33531; Toll-interacting protein
Gene Aliases: 4930403G24Rik; 4931428G15Rik; IL-1RAcPIP; TOLLIP
UniProt ID: (Human) Q9H0E2, (Mouse) Q9QZ06
Entrez Gene ID: (Human) 54472, (Mouse) 54473
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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