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Abnova
TNFRSF14 Monoclonal Antibody (2G6-2C7)
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Product Details
H00008764-M01
Species Reactivity
Host/Isotype
Class
Type
Clone
Immunogen
Conjugate
Form
Concentration
Purification
Storage buffer
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Storage conditions
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Product Specific Information
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: ALPSCKEDEY PVGSECCPKC SPGYRVKEAC GELTGTVCEP CPPGTYIAHL NGLSKCLQCQ MCDPAMGLRA SRNCSRTENA VCGCSPGHFC IVQDGDHCAA CRAYATSSPG QRVQKGGTES QDTLCQNCPP GTFSPNGTLE ECQHQTKCSW LVTKAGAGTS SSHWVWWFLS GSLVIVIVCS TVGLIICVKR RKPRGDVVKV IVSVQRKRQE AEGEATVIEA LQAPPDVTTV AVEETIPSFT GRSPNH
Target Information
TNFRSF14 is a member of the TNF-receptor superfamily. TNFRSF14 was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to TNFRSF14 has been shown to be part of the viral entry mechanism. The cytoplasmic region of TNFRSF14 was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Activation of the signal transduction pathway involving TNFRSF14 in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these TNFRSF14 variants have not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CD270; CD40-like protein; Herpes virus entry mediator A; Herpesvirus entry mediator A; HGNC:11912; RP3-395M20.6; sCD2710; TR2; tumo; Tumor necrosis factor receptor superfamily member 14; tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator); Tumor necrosis factor receptor-like 2; tumor necrosis factor receptor-like gene2
Gene Aliases: ATAR; CD270; HVEA; HVEM; LIGHTR; TNFRSF14; TR2; UNQ329/PRO509
UniProt ID: (Human) Q92956
Entrez Gene ID: (Human) 8764
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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